Endocrine Abstracts

Background: Altering maternal nutrition affects fetal development, potentially predisposing them to later metabolic disease. Tissue sensitivity to cortisol is regulated, in part, by GR and 11βhsd1 and 2, and GR and 11βhsd1 expression is known to be raised both with obesity and type 2 diabetes.Objectives: To examine whether gestational diet influences GR and11βhsd1 and 2 mRNA expression in the neonatal liver.Methods: ...

Background: Birth weight has important consequences for later health, including the development of the metabolic syndrome. Tissue sensitivity to cortisol is regulated, in part, by the GR and alterations in its expression occur in obesity and type 2 diabetes. Low birth weight is associated with increased fat mass and down-regulation of PPARα, in skeletal muscle of neonatal pigs.Objectives: To examine whether birth weight influences GR or PPARα m...